Contribution of Monocarboxylate Transporter 6 to the Pharmacokinetics and Pharmacodynamics of Bumetanide in Mice.

Jones, Robert S; Ruszaj, Donna; Parker, Mark D; Morris, Marilyn E

Jones, Robert S; Ruszaj, Donna; Parker, Mark D; Morris, Marilyn E.

Afiliação

Jones RS; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (R.S.J., D.R., M.E.M.) and Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences (M.D.P.), University at Buffalo, State University of New York, Buffalo, New York.
Ruszaj D; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (R.S.J., D.R., M.E.M.) and Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences (M.D.P.), University at Buffalo, State University of New York, Buffalo, New York.
Parker MD; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (R.S.J., D.R., M.E.M.) and Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences (M.D.P.), University at Buffalo, State University of New York, Buffalo, New York.
Morris ME; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (R.S.J., D.R., M.E.M.) and Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences (M.D.P.), University at Buffalo, State University of New York, Buffalo, New York memorris@buffal

Drug Metab Dispos ; 48(9): 788-795, 2020 09.

Article em En | MEDLINE | ID: mdl-32587098

Assuntos

Bumetanida/farmacocinética; Diurese/efeitos dos fármacos; Transportadores de Ácidos Monocarboxílicos/metabolismo; Inibidores de Simportadores de Cloreto de Sódio e Potássio/farmacocinética; Administração Intravenosa; Administração Oral; Animais; Bumetanida/administração & dosagem; Avaliação Pré-Clínica de Medicamentos; Córtex Renal/efeitos dos fármacos; Córtex Renal/metabolismo; Masculino; Camundongos; Camundongos Knockout; Transportadores de Ácidos Monocarboxílicos/genética; Oócitos; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Inibidores de Simportadores de Cloreto de Sódio e Potássio/administração & dosagem; Xenopus laevis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bumetanida / Transportadores de Ácidos Monocarboxílicos / Diurese / Inibidores de Simportadores de Cloreto de Sódio e Potássio Limite: Animals Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2020 Tipo de documento: Article

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