Iron stored in ferritin is chemically reduced in the presence of aggregating Aß(1-42).

Everett, James; Brooks, Jake; Lermyte, Frederik; O'Connor, Peter B; Sadler, Peter J; Dobson, Jon; Collingwood, Joanna F; Telling, Neil D

Everett, James; Brooks, Jake; Lermyte, Frederik; O'Connor, Peter B; Sadler, Peter J; Dobson, Jon; Collingwood, Joanna F; Telling, Neil D.

Afiliação

Everett J; School of Pharmacy and Bioengineering, Keele University, Stoke-on-Trent, Staffordshire, ST4 7QB, United Kingdom. j.everett@keele.ac.uk.
Brooks J; School of Engineering, University of Warwick, Coventry, CV4 7AL, United Kingdom. j.everett@keele.ac.uk.
Lermyte F; School of Engineering, University of Warwick, Coventry, CV4 7AL, United Kingdom.
O'Connor PB; School of Engineering, University of Warwick, Coventry, CV4 7AL, United Kingdom.
Sadler PJ; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, United Kingdom.
Dobson J; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, United Kingdom.
Collingwood JF; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, United Kingdom.
Telling ND; J. Crayton Pruitt Family Department of Biomedical Engineering & Department of Materials Science and Engineering, University of Florida, Gainesville, Florida, 32611, United States.

Sci Rep ; 10(1): 10332, 2020 06 25.

Article em En | MEDLINE | ID: mdl-32587293

Assuntos

Doença de Alzheimer/patologia; Peptídeos beta-Amiloides/metabolismo; Ferritinas/metabolismo; Ferro/metabolismo; Fragmentos de Peptídeos/metabolismo; Doença de Alzheimer/diagnóstico; Peptídeos beta-Amiloides/ultraestrutura; Biomarcadores/química; Biomarcadores/metabolismo; Ferritinas/química; Ferritinas/ultraestrutura; Humanos; Ferro/química; Microscopia Eletrônica de Transmissão e Varredura; Oxirredução; Estresse Oxidativo; Fragmentos de Peptídeos/ultraestrutura; Agregados Proteicos; Espectrometria por Raios X

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Peptídeos beta-Amiloides / Ferritinas / Doença de Alzheimer / Ferro Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido

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