A framework for simplification of quantitative systems pharmacology models in clinical pharmacology.

Derbalah, Abdallah; Al-Sallami, Hesham; Hasegawa, Chihiro; Gulati, Abhishek; Duffull, Stephen B

Derbalah, Abdallah; Al-Sallami, Hesham; Hasegawa, Chihiro; Gulati, Abhishek; Duffull, Stephen B.

Afiliação

Derbalah A; School of Pharmacy, University of Otago, Dunedin, New Zealand.
Al-Sallami H; School of Pharmacy, University of Otago, Dunedin, New Zealand.
Hasegawa C; School of Pharmacy, University of Otago, Dunedin, New Zealand.
Gulati A; Clinical Pharmacology and Exploratory Development, Astellas Pharma Global Development, Northbrook, Illinois, USA.
Duffull SB; School of Pharmacy, University of Otago, Dunedin, New Zealand.

Br J Clin Pharmacol ; 88(4): 1430-1440, 2022 02.

Article em En | MEDLINE | ID: mdl-32621550

Assuntos

Farmacologia Clínica; Farmacologia; Simulação por Computador; Desenvolvimento de Medicamentos/métodos; Humanos; Modelos Biológicos; Farmacologia em Rede; Farmacologia/métodos

Palavras-chave

complexity; model-order reduction; pharmacological models; quantitative systems pharmacology

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Farmacologia / Farmacologia Clínica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Nova Zelândia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google