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Use of Drug-level Testing and Single-genome Sequencing to Unravel a Case of Human Immunodeficiency Virus Seroconversion on Pre-exposure Prophylaxis.
Spinelli, Matthew A; Lowery, Brentton; Shuford, Jennifer A; Spindler, Jon; Kearney, Mary F; McFarlane, Jenny R; McDonald, Cheryl; Okochi, Hideaki; Phung, Nhi; Kuncze, Karen; Jee, Kathryn; Johannessen, DeeJay; Anderson, Peter L; Smith, Dawn K; Defechereux, Patricia; Grant, Robert M; Gandhi, Monica.
Afiliação
  • Spinelli MA; Division of Human Immunodeficiency Virus, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Lowery B; Health Education Learning Project, Ft. Worth, Texas, USA.
  • Shuford JA; Texas Department of State Health Services, Austin, Texas, USA.
  • Spindler J; Human Immunodeficiency Virus Dynamics and Replication Program, National Cancer Institute/National Institutes of Health, Ft. Worth, Texas, USA.
  • Kearney MF; Human Immunodeficiency Virus Dynamics and Replication Program, National Cancer Institute/National Institutes of Health, Ft. Worth, Texas, USA.
  • McFarlane JR; Texas Department of State Health Services, Austin, Texas, USA.
  • McDonald C; Texas Centers for Infectious Disease Associates, Ft. Worth, Texas, USA.
  • Okochi H; Division of Human Immunodeficiency Virus, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Phung N; Division of Human Immunodeficiency Virus, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Kuncze K; Division of Human Immunodeficiency Virus, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Jee K; Division of Pulmonary Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Johannessen D; Health Education Learning Project, Ft. Worth, Texas, USA.
  • Anderson PL; Department of Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, USA.
  • Smith DK; Division of Human Immunodeficiency Virus/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Defechereux P; Division of Pulmonary Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Grant RM; Division of Pulmonary Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Gandhi M; Division of Human Immunodeficiency Virus, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Clin Infect Dis ; 72(11): 2025-2028, 2021 06 01.
Article em En | MEDLINE | ID: mdl-32686825
ABSTRACT
Cases of seroconversion on pre-exposure prophylaxis (PrEP) should be carefully investigated, given their public health implications and rarity. We report a case of transmitted drug resistance causing seroconversion on PrEP in spite of high adherence, confirmed with dried blood spot and segmental hair drug-level testing and single-genome sequencing.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Infecções por HIV / Fármacos Anti-HIV / Profilaxia Pré-Exposição Limite: Humans Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Infecções por HIV / Fármacos Anti-HIV / Profilaxia Pré-Exposição Limite: Humans Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos