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Circulating Pregenomic Hepatitis B Virus RNA Is Primarily Full-length in Chronic Hepatitis B Patients Undergoing Nucleos(t)ide Analogue Therapy.
Anderson, Mark; Gersch, Jeffery; Luk, Ka-Cheung; Dawson, George; Carey, Ivana; Agarwal, Kosh; Shah, Pir; Dusheiko, Geoffrey; Lau, Daryl; Cloherty, Gavin.
Afiliação
  • Anderson M; Abbott Laboratories, Infectious Disease Core Diagnostics Department, Abbott Diagnostics Division, Abbott Park, Illinois, USA.
  • Gersch J; Abbott Laboratories, Infectious Disease Core Diagnostics Department, Abbott Diagnostics Division, Abbott Park, Illinois, USA.
  • Luk KC; Abbott Laboratories, Infectious Disease Core Diagnostics Department, Abbott Diagnostics Division, Abbott Park, Illinois, USA.
  • Dawson G; Abbott Laboratories, Infectious Disease Core Diagnostics Department, Abbott Diagnostics Division, Abbott Park, Illinois, USA.
  • Carey I; King's College, Department of Infectious Diseases, London, United Kingdom.
  • Agarwal K; Institute of Liver Studies, King's College Hospital, London, United Kingdom.
  • Shah P; Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Dusheiko G; Institute of Liver Studies, King's College Hospital, London, United Kingdom.
  • Lau D; Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Cloherty G; Abbott Laboratories, Infectious Disease Core Diagnostics Department, Abbott Diagnostics Division, Abbott Park, Illinois, USA.
Clin Infect Dis ; 72(11): 2029-2031, 2021 06 01.
Article em En | MEDLINE | ID: mdl-32687164
ABSTRACT
Hepatitis B virus RNA is detectable in the serum of infected patients; however, the RNA species has been questioned. We tested 1827 specimens using a quantitative dual-target quantitative polymerase chain reaction assay and determined that full-length pregenomic RNA is the primary source. These results clarify the major identity of circulating HBV RNA species.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatite B Crônica / Ácidos Nucleicos Livres / Hepatite B Limite: Humans Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatite B Crônica / Ácidos Nucleicos Livres / Hepatite B Limite: Humans Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos