Natural Polyketides Isolated from the Endophytic Fungus Phomopsis sp. CAM212 with a Semisynthetic Derivative Downregulating the ERK/I&#954;B&#945; Signaling Pathways.

Jouda, Jean-Bosco; Njoya, Emmanuel Mfotie; Fobofou, Serge Alain Tanemossu; Zhou, Zong Yuan; Qiang, Zhe; Mbazoa, Céline Djama; Brandt, Wolfgang; Zhang, Guo-Lin; Wandji, Jean; Wang, Fei

Natural Polyketides Isolated from the Endophytic Fungus Phomopsis sp. CAM212 with a Semisynthetic Derivative Downregulating the ERK/IκBα Signaling Pathways.

Jouda, Jean-Bosco; Njoya, Emmanuel Mfotie; Fobofou, Serge Alain Tanemossu; Zhou, Zong Yuan; Qiang, Zhe; Mbazoa, Céline Djama; Brandt, Wolfgang; Zhang, Guo-Lin; Wandji, Jean; Wang, Fei.

Afiliação

Jouda JB; Department of Chemical Engineering, School of Chemical Engineering and Mineral Industries, University of Ngaoundere, Ngaoundere, Cameroon.
Njoya EM; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.
Fobofou SAT; Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
Zhou ZY; Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany.
Qiang Z; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, USA.
Mbazoa CD; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.
Brandt W; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.
Zhang GL; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
Wandji J; Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany.
Wang F; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.

Planta Med ; 86(13-14): 1032-1042, 2020 Sep.

Article em En | MEDLINE | ID: mdl-32757200

Assuntos

Policetídeos/farmacologia; Animais; Ciclo-Oxigenase 2; Lipopolissacarídeos; Sistema de Sinalização das MAP Quinases; Camundongos; Inibidor de NF-kappaB alfa; NF-kappa B; Óxido Nítrico; Óxido Nítrico Sintase Tipo II; Transdução de Sinais

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Policetídeos Limite: Animals Idioma: En Revista: Planta Med Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Camarões

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