Integrative analyses of single-cell transcriptome and regulome using MAESTRO.

Wang, Chenfei; Sun, Dongqing; Huang, Xin; Wan, Changxin; Li, Ziyi; Han, Ya; Qin, Qian; Fan, Jingyu; Qiu, Xintao; Xie, Yingtian; Meyer, Clifford A; Brown, Myles; Tang, Ming; Long, Henry; Liu, Tao; Liu, X Shirley

Wang, Chenfei; Sun, Dongqing; Huang, Xin; Wan, Changxin; Li, Ziyi; Han, Ya; Qin, Qian; Fan, Jingyu; Qiu, Xintao; Xie, Yingtian; Meyer, Clifford A; Brown, Myles; Tang, Ming; Long, Henry; Liu, Tao; Liu, X Shirley.

Afiliação

Wang C; Department of Data Science, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, 02215, USA.
Sun D; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Huang X; Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Science and Technology, Tongji University, Shanghai, 200433, China.
Wan C; Beijing Institute of Radiation Medicine, Beijing, 100850, China.
Li Z; Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Science and Technology, Tongji University, Shanghai, 200433, China.
Han Y; Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Science and Technology, Tongji University, Shanghai, 200433, China.
Qin Q; Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Science and Technology, Tongji University, Shanghai, 200433, China.
Fan J; Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Science and Technology, Tongji University, Shanghai, 200433, China.
Qiu X; Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Science and Technology, Tongji University, Shanghai, 200433, China.
Xie Y; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Meyer CA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA.
Brown M; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Tang M; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA.
Long H; Department of Data Science, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, 02215, USA.
Liu T; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Liu XS; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.

Genome Biol ; 21(1): 198, 2020 08 07.

Article em En | MEDLINE | ID: mdl-32767996

Assuntos

Regulação da Expressão Gênica; Modelos Genéticos; Análise de Célula Única; Software; Transcriptoma; Células da Medula Óssea/metabolismo; Estudos de Casos e Controles; Humanos; Leucemia Linfocítica Crônica de Células B/metabolismo; Análise de Sequência de RNA; Microambiente Tumoral

Palavras-chave

Cell-type annotation; Computational workflow; Integrate scRNA-seq and scATAC-seq; Predict transcriptional regulators; Single-cell ATAC-seq; Single-cell RNA-seq

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Software / Regulação da Expressão Gênica / Análise de Célula Única / Transcriptoma / Modelos Genéticos Tipo de estudo: Evaluation_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Genome Biol Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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