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[Effects of estradiol on the day of human chorionic gonadotropin administration on adverse perinatal outcomes].
Chen, R; Tao, S Y; Du, J B; Diao, F Y; Hu, Z B.
Afiliação
  • Chen R; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
  • Tao SY; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
  • Du JB; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
  • Diao FY; Reproduction Medicine Centre, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
  • Hu ZB; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Zhonghua Yu Fang Yi Xue Za Zhi ; 54(6): 651-656, 2020 Jun 06.
Article em Zh | MEDLINE | ID: mdl-32842281
Objective: To investigate the association between estradiol on the day of human chorionic gonadotropin (HCG) administration and birth outcomes among singleton live births following fresh embryo transfers. Methods: Based on the clinical reproduction medicine management system of the First Affiliated Hospital of Nanjing Medical University, this retrospective cohort study collected data of fresh embryo transfer cycles during January 2013 and December 2016, including pregnant women's age, body mass index (BMI), type and cause of infertility, assisted reproductive therapy indicators (fertilization mode, ovulation stimulation protocol, estradiol levels on HCG administration day), adverse birth outcomes[small for gestational age (SGA), premature and low birth weight (LBW)], etc.. A total of 2 060 women with singleton pregnancy (2 061 fresh embryo transfer cycles) were enrolled. Multivariate logistic regression was used to analyze the association between estradiol on HCG administration day and singletons' adverse birth outcomes. Results: The age and BMI of the 2 060 pregnant women were (29.63±3.92) years old and (22.29±2.86) kg/m2. Incidences of SGA, premature and LBW were 9.8% (201/2 061), 6.9% (143/2 061) and 3.5% (73/2 061), respectively. After adjusting for confounders, the risk of LBW in 4 000-4 499 pg/ml group was significantly elevated when compared to estradiol<1 500 pg/ml group [OR (95%CI): 4.42 (1.13-17.24)]. A protective effect of premature was observed in estradiol≥4 500 pg/ml group [OR (95%CI): 0.50 (0.25-0.97)]. Conclusion: The high level of estradiol on HCG administration day might be a risk factor for LBW, but a protective factor for premature.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fertilização in vitro / Estradiol Tipo de estudo: Guideline / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Newborn / Pregnancy Idioma: Zh Revista: Zhonghua Yu Fang Yi Xue Za Zhi Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fertilização in vitro / Estradiol Tipo de estudo: Guideline / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Newborn / Pregnancy Idioma: Zh Revista: Zhonghua Yu Fang Yi Xue Za Zhi Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China