Baicalensines A and B, Two Isoquinoline Alkaloids from the Roots of Thalictrum baicalense.
Org Lett
; 22(19): 7439-7442, 2020 10 02.
Article
em En
| MEDLINE
| ID: mdl-32886519
ABSTRACT
Baicalensines A (1) and B (2) were isolated from the roots of Thalictrum baicalense and structurally characterized using spectroscopic data, 13C NMR calculations, and the CASE algorithm. Compound 1, representing a new class of alkaloid dimers, contains berberine conjugated to a ring-opened isoquinoline. Compound 2 is the first reported natural benzylisoquinoline bearing a formyl group at C-3. Plausible biosynthetic pathways are proposed. Compound 1 exerted moderate cytotoxicity against the Caco-2 and HL-60 cell lines.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Berberina
/
Thalictrum
/
Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2020
Tipo de documento:
Article