Upregulation of serum and glucocorticoid-regulated kinase 1 exacerbates brain injury and neurological deficits after cardiac arrest.

Lee, Reggie Hui-Chao; Grames, Mychal S; Wu, Celeste Yin-Chieh; Lien, Chih-Feng; Couto E Silva, Alexandre; Possoit, HarLee E; Clemons, Garrett A; Citadin, Cristiane T; Neumann, Jake T; Pastore, Donatella; Lauro, Davide; Della-Morte, David; Lin, Hung Wen

Lee, Reggie Hui-Chao; Grames, Mychal S; Wu, Celeste Yin-Chieh; Lien, Chih-Feng; Couto E Silva, Alexandre; Possoit, HarLee E; Clemons, Garrett A; Citadin, Cristiane T; Neumann, Jake T; Pastore, Donatella; Lauro, Davide; Della-Morte, David; Lin, Hung Wen.

Afiliação

Lee RH; Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
Grames MS; Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
Wu CY; Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
Lien CF; Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
Couto E Silva A; Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
Possoit HE; Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
Clemons GA; Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
Citadin CT; Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
Neumann JT; Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
Pastore D; Department of Biomedical Sciences, West Virginia School of Osteopathic Medicine, Lewisburg, West Virginia.
Lauro D; Department of Systems Medicine, University of Rome Tor Vergata, Rome. Italy.
Della-Morte D; Department of Systems Medicine, University of Rome Tor Vergata, Rome. Italy.
Lin HW; Department of Systems Medicine, University of Rome Tor Vergata, Rome. Italy.

Am J Physiol Heart Circ Physiol ; 319(5): H1044-H1050, 2020 11 01.

Article em En | MEDLINE | ID: mdl-32946263

Assuntos

Lesões Encefálicas/metabolismo; Parada Cardíaca/complicações; Proteínas Imediatamente Precoces/genética; Memória; Proteínas Serina-Treonina Quinases/genética; Animais; Benzoatos/farmacologia; Lesões Encefálicas/tratamento farmacológico; Lesões Encefálicas/etiologia; Compostos Bicíclicos Heterocíclicos com Pontes/farmacologia; Circulação Cerebrovascular; Hipocampo/efeitos dos fármacos; Hipocampo/metabolismo; Proteínas Imediatamente Precoces/antagonistas & inibidores; Proteínas Imediatamente Precoces/metabolismo; Masculino; Fármacos Neuroprotetores/farmacologia; Fármacos Neuroprotetores/uso terapêutico; Inibidores de Proteínas Quinases/farmacologia; Proteínas Serina-Treonina Quinases/antagonistas & inibidores; Proteínas Serina-Treonina Quinases/metabolismo; Ratos; Ratos Sprague-Dawley; Regulação para Cima

Palavras-chave

cerebral blood flow; cerebral ischemia; neuroinflammation; neuronal cell death; serum and glucocorticoid-regulated kinase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lesões Encefálicas / Proteínas Serina-Treonina Quinases / Proteínas Imediatamente Precoces / Parada Cardíaca / Memória Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Am J Physiol Heart Circ Physiol Assunto da revista: CARDIOLOGIA / FISIOLOGIA Ano de publicação: 2020 Tipo de documento: Article

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