Topical ripasudil stimulates neuroprotection and axon regeneration in adult mice following optic nerve injury.
Sci Rep
; 10(1): 15709, 2020 09 24.
Article
em En
| MEDLINE
| ID: mdl-32973242
ABSTRACT
Optic nerve injury induces optic nerve degeneration and retinal ganglion cell (RGC) death that lead to visual disturbance. In this study, we examined if topical ripasudil has therapeutic potential in adult mice after optic nerve crush (ONC). Topical ripasudil suppressed ONC-induced phosphorylation of p38 mitogen-activated protein kinase and ameliorated RGC death. In addition, topical ripasudil significantly suppressed the phosphorylation of collapsin response mediator protein 2 and cofilin, and promoted optic nerve regeneration. These results suggest that topical ripasudil promotes RGC protection and optic nerve regeneration by modulating multiple signaling pathways associated with neural cell death, microtubule assembly and actin polymerization.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Sulfonamidas
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Fármacos Neuroprotetores
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Traumatismos do Nervo Óptico
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Isoquinolinas
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Regeneração Nervosa
Limite:
Animals
Idioma:
En
Revista:
Sci Rep
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Japão