Standardized microfluidic assessment of red blood cell-mediated microcapillary occlusion: Association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease.

Man, Yuncheng; Kucukal, Erdem; An, Ran; Bode, Allison; Little, Jane A; Gurkan, Umut A

Man, Yuncheng; Kucukal, Erdem; An, Ran; Bode, Allison; Little, Jane A; Gurkan, Umut A.

Afiliação

Man Y; Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, USA.
Kucukal E; Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, USA.
An R; Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, USA.
Bode A; Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, USA.
Little JA; Division of Hematology and Oncology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Gurkan UA; Division of Hematology and Oncology, Department of Medicine, UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Microcirculation ; 28(2): e12662, 2021 02.

Article em En | MEDLINE | ID: mdl-33025653

Assuntos

Anemia Falciforme; Hidroxiureia; Anemia Falciforme/tratamento farmacológico; Eritrócitos; Hemoglobinas; Humanos; Hidroxiureia/uso terapêutico; Microcirculação; Microfluídica; Fenótipo

Palavras-chave

Erythrocytes; microcirculation; microfluidics; microvascular occlusion; sickle cell disease

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidroxiureia / Anemia Falciforme Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Microcirculation Assunto da revista: ANGIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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