The index of oxygenation to respiratory rate as a prognostic factor for mortality in Sepsis.
Am J Emerg Med
; 45: 426-432, 2021 07.
Article
em En
| MEDLINE
| ID: mdl-33039213
ABSTRACT
OBJECTIVES:
An index combining respiratory rate and oxygenation (ROX) has been introduced, and the ROX index is defined as the ratio of oxygen saturation by pulse oximetry/fraction of inspired oxygen to respiratory rate. In sepsis, hypoxemia and tachypnea are commonly observed. We performed this study to investigate the association between the ROX index and 28-day mortality in patients with sepsis or septic shock.METHODS:
This retrospective study included 2862 patients. The patients were divided into three groups according to the ROX index Group I (ROX index >20), Group II (ROX index >10 and ≤ 20), and Group III (ROX index ≤10).RESULTS:
The median ROX index was significantly lower in the nonsurvivors than in the survivors (12.8 and 18.2, respectively) (p < 0.001). The 28-day mortality rates in Groups I, II and III were 14.5%, 21.3% and 34.4%, respectively (p < 0.001). In the multivariable Cox regression analysis, Group III had an approximately 40% higher risk of death than Group I during the 28-day period (hazard ratio = 1.41, 95% confidence interval 1.13-1.76). The area under the curve of the ROX index was significantly higher than that of the quick Sequential Organ Failure Assessment score (p < 0.001).CONCLUSIONS:
The ROX index was lower in nonsurvivors than in survivors, and a ROX index less than or equal to 10 was an independent prognostic factor for 28-day mortality in patients with sepsis or septic shock. Therefore, the ROX index could be used as a prognostic marker in sepsis.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Choque Séptico
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Gasometria
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Oximetria
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Taxa Respiratória
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
Am J Emerg Med
Ano de publicação:
2021
Tipo de documento:
Article