Structural rearrangement of amyloid-ß upon inhibitor binding suppresses formation of Alzheimer's disease related oligomers.

Lieblein, Tobias; Zangl, Rene; Martin, Janosch; Hoffmann, Jan; Hutchison, Marie J; Stark, Tina; Stirnal, Elke; Schrader, Thomas; Schwalbe, Harald; Morgner, Nina

Lieblein, Tobias; Zangl, Rene; Martin, Janosch; Hoffmann, Jan; Hutchison, Marie J; Stark, Tina; Stirnal, Elke; Schrader, Thomas; Schwalbe, Harald; Morgner, Nina.

Afiliação

Lieblein T; JW Goethe-University, Institute of Physical and Theoretical Chemistry, Frankfurt, Germany.
Zangl R; JW Goethe-University, Institute of Physical and Theoretical Chemistry, Frankfurt, Germany.
Martin J; JW Goethe-University, Institute of Physical and Theoretical Chemistry, Frankfurt, Germany.
Hoffmann J; JW Goethe-University, Institute of Physical and Theoretical Chemistry, Frankfurt, Germany.
Hutchison MJ; JW Goethe-University, Institute for Organic Chemistry and Chemical Biology and Center for Biomolecular Magnetic Resonance, Frankfurt am Main, Germany.
Stark T; JW Goethe-University, Institute for Organic Chemistry and Chemical Biology and Center for Biomolecular Magnetic Resonance, Frankfurt am Main, Germany.
Stirnal E; JW Goethe-University, Institute for Organic Chemistry and Chemical Biology and Center for Biomolecular Magnetic Resonance, Frankfurt am Main, Germany.
Schrader T; University of Duisburg-Essen, Institute of Organic Chemistry, Essen, Germany.
Schwalbe H; JW Goethe-University, Institute for Organic Chemistry and Chemical Biology and Center for Biomolecular Magnetic Resonance, Frankfurt am Main, Germany.
Morgner N; JW Goethe-University, Institute of Physical and Theoretical Chemistry, Frankfurt, Germany.

Elife ; 92020 10 23.

Article em En | MEDLINE | ID: mdl-33095161

Assuntos

Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides/química; Peptídeos beta-Amiloides/metabolismo; Doença de Alzheimer/genética; Peptídeos beta-Amiloides/genética; Humanos; Ligantes; Espectrometria de Massas; Modelos Moleculares; Agregados Proteicos

Palavras-chave

E. coli; aggregation; amyloid beta-peptides; conformation analysis; ion mobility spectrometry; mass spectrometry; neuroscience

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Doença de Alzheimer Limite: Humans Idioma: En Revista: Elife Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha

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