Your browser doesn't support javascript.
loading
Predictive value of early cardiac magnetic resonance imaging functional and geometric indexes for adverse left ventricular remodelling in patients with anterior ST-segment elevation myocardial infarction: A report from the CIRCUS study.
Pezel, Théo; Besseyre des Horts, Timothée; Schaaf, Mathieu; Croisille, Pierre; Bière, Loïc; Garcia-Dorado, David; Jossan, Claire; Roubille, François; Cung, Thien-Tri; Prunier, Fabrice; Meyer, Elbaz; Amaz, Camille; Derumeaux, Geneviève; de Poli, Fabien; Hovasse, Thomas; Gilard, Martine; Bergerot, Cyrille; Thibault, Hélène; Ovize, Michel; Mewton, Nathan.
Afiliação
  • Pezel T; Inserm, UMRS 942, Department of Cardiology, Lariboisière Hospital, Paris University, AP-HP, 75010 Paris, France; Division of Cardiology, Johns-Hopkins University, 21287-0409 Baltimore, MD, USA.
  • Besseyre des Horts T; Inserm 1407, Clinical Investigation Centre and Heart Failure Department, Cardiovascular Hospital Louis-Pradel, hospices civils de Lyon, université Claude-Bernard Lyon 1, 69677 Bron, France.
  • Schaaf M; Inserm 1407, Clinical Investigation Centre and Heart Failure Department, Cardiovascular Hospital Louis-Pradel, hospices civils de Lyon, université Claude-Bernard Lyon 1, 69677 Bron, France.
  • Croisille P; Radiology Department, University Hospital of Saint-Étienne, 42270 Saint-Priest-en-Jarez, France.
  • Bière L; Cardiology Division, University Hospital of Angers, 49100 Angers, France.
  • Garcia-Dorado D; CIBERCV, Hospital Universitari Vall d'Hebron & Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.
  • Jossan C; Inserm 1407, Clinical Investigation Centre and Heart Failure Department, Cardiovascular Hospital Louis-Pradel, hospices civils de Lyon, université Claude-Bernard Lyon 1, 69677 Bron, France.
  • Roubille F; UMR5203, UMR661, Cardiology Division, University Hospital of Montpellier, University of Montpellier 1 and 2, 34295 Montpellier, France.
  • Cung TT; UMR5203, UMR661, Cardiology Division, University Hospital of Montpellier, University of Montpellier 1 and 2, 34295 Montpellier, France.
  • Prunier F; Cardiology Division, University Hospital of Angers, 49100 Angers, France.
  • Meyer E; Rangeuil Hospital, University Hospital of Toulouse, Paul-Sabatier University, 31400 Toulouse, France.
  • Amaz C; Inserm 1407, Clinical Investigation Centre and Heart Failure Department, Cardiovascular Hospital Louis-Pradel, hospices civils de Lyon, université Claude-Bernard Lyon 1, 69677 Bron, France.
  • Derumeaux G; DHU-ATVB, Henri-Mondor Hospital, Paris-Est Créteil University, AP-HP, 94010 Créteil, France.
  • de Poli F; Cardiology Division, Haguenau Hospital, 67500 Haguenau, France.
  • Hovasse T; Cardiology Division, Jacques-Cartier Institute, 91300 Massy, France.
  • Gilard M; Department of Cardiology, Brest University Hospital, 29200 Brest, France.
  • Bergerot C; Inserm 1407, Clinical Investigation Centre and Heart Failure Department, Cardiovascular Hospital Louis-Pradel, hospices civils de Lyon, université Claude-Bernard Lyon 1, 69677 Bron, France.
  • Thibault H; Inserm 1407, Clinical Investigation Centre and Heart Failure Department, Cardiovascular Hospital Louis-Pradel, hospices civils de Lyon, université Claude-Bernard Lyon 1, 69677 Bron, France.
  • Ovize M; Inserm 1407, Clinical Investigation Centre and Heart Failure Department, Cardiovascular Hospital Louis-Pradel, hospices civils de Lyon, université Claude-Bernard Lyon 1, 69677 Bron, France.
  • Mewton N; Inserm 1407, Clinical Investigation Centre and Heart Failure Department, Cardiovascular Hospital Louis-Pradel, hospices civils de Lyon, université Claude-Bernard Lyon 1, 69677 Bron, France. Electronic address: nathan.mewton@chu-lyon.fr.
Arch Cardiovasc Dis ; 113(11): 710-720, 2020 Nov.
Article em En | MEDLINE | ID: mdl-33160891
BACKGROUND: Postinfarction adverse left ventricular (LV) remodelling is strongly associated with heart failure events. Conicity index, sphericity index and LV global functional index (LVGFI) are new LV remodelling indexes assessed by cardiac magnetic resonance (CMR). AIM: To assess the predictive value of the new indexes for 1-year adverse LV remodelling in patients with anterior ST-segment elevated myocardial infarction (STEMI). METHODS: CMR studies were performed in 129 patients with anterior STEMI (58±12 years; 78% men) from the randomized CIRCUS trial (CMR substudy) treated with primary percutaneous coronary intervention and followed for the occurrence of major adverse cardiovascular events (MACE) (death or hospitalization for heart failure). Conicity index, sphericity index, LVGFI, infarct size and microvascular obstruction (MVO) were assessed by CMR performed 5±4 days after coronary reperfusion. Adverse LV remodelling was defined as an increase in LV end-diastolic volume of ≥15% by transthoracic echocardiography at 1 year. RESULTS: Adverse LV remodelling occurred in 27% of patients at 1 year. Infarct size and MVO were significantly predictive of adverse LV remodelling: odds ratio [OR] 1.03, 95% confidence interval [CI] 1.01-1.05 (P<0.001) and OR 1.12, 95% CI 1.05-1.22 (P<0.001), respectively. Among the newly tested indexes, only LVGFI was significantly predictive of adverse LV remodelling (OR 1.10, 95% CI 1.03-1.16; P=0.001). In multivariable analysis, infarct size remained an independent predictor of adverse LV remodelling at 1 year (OR 1.05, 95% CI 1.02-1.08; P<0.001). LVGFI and infarct size were associated with occurrence of MACE: OR 1.21, 95% CI 1.08-1.37 (P<0.001) and OR 1.02, 95% CI 1.00-1.04 (P=0.018), respectively. Conicity and sphericity indexes were not associated with MACE. CONCLUSIONS: LVGFI was associated with adverse LV remodelling and MACE 1 year after anterior STEMI.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Função Ventricular Esquerda / Imagem Cinética por Ressonância Magnética / Remodelação Ventricular / Infarto Miocárdico de Parede Anterior / Infarto do Miocárdio com Supradesnível do Segmento ST Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Arch Cardiovasc Dis Assunto da revista: ANGIOLOGIA / CARDIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Função Ventricular Esquerda / Imagem Cinética por Ressonância Magnética / Remodelação Ventricular / Infarto Miocárdico de Parede Anterior / Infarto do Miocárdio com Supradesnível do Segmento ST Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Arch Cardiovasc Dis Assunto da revista: ANGIOLOGIA / CARDIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos