Magnesium deficiency with high calcium-to-magnesium ratio promotes a metastatic phenotype in the CT26 colon cancer cell line.

Kumar, Gopal; Chatterjee, Prodyot K; Madankumar, Swati; Mehdi, Syed F; Xue, Xiangying; Metz, Christine N

Kumar, Gopal; Chatterjee, Prodyot K; Madankumar, Swati; Mehdi, Syed F; Xue, Xiangying; Metz, Christine N.

Afiliação

Kumar G; Elmezzi Graduate School of Molecular Medicine, Northwell Health, 350 Community Drive, Manhasset, 11030, New York, United States.
Chatterjee PK; Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, 11030, New York, United States.
Madankumar S; Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, 11030, New York, United States.
Mehdi SF; Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, 11030, New York, United States.
Xue X; Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, 11030, New York, United States.
Metz CN; Elmezzi Graduate School of Molecular Medicine, Northwell Health, 350 Community Drive, Manhasset, 11030, New York, United States, Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, 11030, New York, United States, Donald and Ba

Magnes Res ; 33(3): 68-85, 2020 Aug 01.

Article em En | MEDLINE | ID: mdl-33210606

Assuntos

Cálcio/metabolismo; Neoplasias do Colo/metabolismo; Deficiência de Magnésio/metabolismo; Magnésio/metabolismo; Cálcio/análise; Calpaína/genética; Calpaína/metabolismo; Humanos; Magnésio/análise; Estresse Oxidativo; Fenótipo; Proteínas Serina-Treonina Quinases/genética; Proteínas Serina-Treonina Quinases/metabolismo; Canais de Cátion TRPM/genética; Canais de Cátion TRPM/metabolismo; Células Tumorais Cultivadas

Palavras-chave

CT26 cell line; calcium-to-magnesium ratio; calpain activity; cell migration; focal adhesion kinase; genomic instability; magnesium deficiency; oxidative stress

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cálcio / Neoplasias do Colo / Magnésio / Deficiência de Magnésio Limite: Humans Idioma: En Revista: Magnes Res Assunto da revista: FARMACOLOGIA / METABOLISMO / TERAPIA POR MEDICAMENTOS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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