Implications of Oligomeric Amyloid-Beta (oAß<sub>42</sub>) Signaling through &#945;7ß2-Nicotinic Acetylcholine Receptors (nAChRs) on Basal Forebrain Cholinergic Neuronal Intrinsic Excitability and Cognitive Decline.

George, Andrew A; Vieira, Jaime M; Xavier-Jackson, Cameron; Gee, Michael T; Cirrito, John R; Bimonte-Nelson, Heather A; Picciotto, Marina R; Lukas, Ronald J; Whiteaker, Paul

Implications of Oligomeric Amyloid-Beta (oAß₄₂) Signaling through α7ß2-Nicotinic Acetylcholine Receptors (nAChRs) on Basal Forebrain Cholinergic Neuronal Intrinsic Excitability and Cognitive Decline.

George, Andrew A; Vieira, Jaime M; Xavier-Jackson, Cameron; Gee, Michael T; Cirrito, John R; Bimonte-Nelson, Heather A; Picciotto, Marina R; Lukas, Ronald J; Whiteaker, Paul.

Afiliação

George AA; Department of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013 Andrew.George@dignityhealth.org.
Vieira JM; Department of Psychology, Arizona State University, Tempe, Arizona 87110.
Xavier-Jackson C; Department of Pharmacology, University of Bath, Bath, BA2 7AY, United Kingdom.
Gee MT; Department of Physiology, Banner-University Medical Center, University of Arizona, Tucson, Arizona 85724.
Cirrito JR; Division of Biology and Biomedical Sciences, Washington University, St. Louis, Missouri 63110.
Bimonte-Nelson HA; Department of Psychology, Arizona State University, Tempe, Arizona 87110.
Picciotto MR; Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06519.
Lukas RJ; Department of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013.
Whiteaker P; Department of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013.

J Neurosci ; 41(3): 555-575, 2021 01 20.

Article em En | MEDLINE | ID: mdl-33239400

Assuntos

Peptídeos beta-Amiloides/genética; Prosencéfalo Basal/fisiopatologia; Disfunção Cognitiva/genética; Disfunção Cognitiva/fisiopatologia; Sistema Nervoso Parassimpático/fisiopatologia; Fragmentos de Peptídeos/genética; Transdução de Sinais/genética; Receptor Nicotínico de Acetilcolina alfa7/genética; Precursor de Proteína beta-Amiloide/genética; Animais; Linhagem Celular; Fenômenos Eletrofisiológicos; Feminino; Genótipo; Humanos; Masculino; Aprendizagem em Labirinto; Camundongos; Camundongos Transgênicos; Neurônios/patologia

Palavras-chave

basal forebrain cholinergic neurons; medium afterhyperpolarization; neuronal intrinsic excitability; oligomeric amyloid-beta; single-channel electrophysiology; spatial reference memory

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema Nervoso Parassimpático / Fragmentos de Peptídeos / Transdução de Sinais / Peptídeos beta-Amiloides / Disfunção Cognitiva / Receptor Nicotínico de Acetilcolina alfa7 / Prosencéfalo Basal Limite: Animals / Female / Humans / Male Idioma: En Revista: J Neurosci Ano de publicação: 2021 Tipo de documento: Article

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