Hospital-based Surveillance for Pediatric Norovirus Gastroenteritis in Bangladesh, 2012-2016.
Pediatr Infect Dis J
; 40(3): 215-219, 2021 03 01.
Article
em En
| MEDLINE
| ID: mdl-33264214
ABSTRACT
BACKGROUND:
Globally, noroviruses are recognized as an important cause of acute gastroenteritis (AGE), but data from low and middle-income countries are limited.AIMS:
To examine the epidemiology and strain diversity of norovirus infections among children hospitalized for AGE in Bangladesh.METHODS:
We implemented active surveillance of children <5 years of age hospitalized with AGE at 8 geographically dispersed tertiary care hospitals in Bangladesh from July 2012 to June 2016. We tested random samples of AGE cases stratified by site and age group for norovirus by real-time RT-PCR. Noro-positive specimens were genotyped. Coinfection with rotavirus was assessed based on prior EIA testing.RESULTS:
We enrolled 5622 total AGE cases, of which 1008 were tested for norovirus. Total of 137 (14%) AGE cases tested positive for norovirus (range, 11%-17% by site). Most (94%) norovirus-associated hospitalizations were among children less than 2 years of age. Norovirus was detected year-round, with higher detection from March to June (20%-38%) and November to January (9%-18%). Genogroup II (GII) noroviruses were detected in 96% of cases, and the most frequent genotypes were GII.4 Sydney [P4 New Orleans] (33%), GII.3 [P16] (20%), and GII.4 Sydney [P16] (11%). The proportion of norovirus-positive specimens was significantly greater among rotavirus-negative AGE patients compared with rotavirus-positive AGE patients (27% vs. 5%, P < 0.001). As measured by the Vesikari severity score, a similar proportion of norovirus and rotavirus positive AGE patients were considered severe (68% vs. 70%, P = 0.86).CONCLUSIONS:
Norovirus is an important cause of AGE hospitalization in Bangladeshi children with most infections caused by GII viruses.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vigilância da População
/
Infecções por Caliciviridae
/
Norovirus
/
Gastroenterite
Tipo de estudo:
Clinical_trials
/
Screening_studies
Limite:
Child, preschool
/
Humans
/
Infant
País/Região como assunto:
Asia
Idioma:
En
Revista:
Pediatr Infect Dis J
Assunto da revista:
DOENCAS TRANSMISSIVEIS
/
PEDIATRIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Bangladesh