Molecular and evolutionary processes generating variation in gene expression.
Nat Rev Genet
; 22(4): 203-215, 2021 04.
Article
em En
| MEDLINE
| ID: mdl-33268840
ABSTRACT
Heritable variation in gene expression is common within and between species. This variation arises from mutations that alter the form or function of molecular gene regulatory networks that are then filtered by natural selection. High-throughput methods for introducing mutations and characterizing their cis- and trans-regulatory effects on gene expression (particularly, transcription) are revealing how different molecular mechanisms generate regulatory variation, and studies comparing these mutational effects with variation seen in the wild are teasing apart the role of neutral and non-neutral evolutionary processes. This integration of molecular and evolutionary biology allows us to understand how the variation in gene expression we see today came to be and to predict how it is most likely to evolve in the future.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Seleção Genética
/
Regulação da Expressão Gênica
/
Evolução Molecular
Idioma:
En
Revista:
Nat Rev Genet
Assunto da revista:
GENETICA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos