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Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination.
Yu, Jiali; Green, Michael D; Li, Shasha; Sun, Yilun; Journey, Sara N; Choi, Jae Eun; Rizvi, Syed Monem; Qin, Angel; Waninger, Jessica J; Lang, Xueting; Chopra, Zoey; El Naqa, Issam; Zhou, Jiajia; Bian, Yingjie; Jiang, Long; Tezel, Alangoya; Skvarce, Jeremy; Achar, Rohan K; Sitto, Merna; Rosen, Benjamin S; Su, Fengyun; Narayanan, Sathiya P; Cao, Xuhong; Wei, Shuang; Szeliga, Wojciech; Vatan, Linda; Mayo, Charles; Morgan, Meredith A; Schonewolf, Caitlin A; Cuneo, Kyle; Kryczek, Ilona; Ma, Vincent T; Lao, Christopher D; Lawrence, Theodore S; Ramnath, Nithya; Wen, Fei; Chinnaiyan, Arul M; Cieslik, Marcin; Alva, Ajjai; Zou, Weiping.
Afiliação
  • Yu J; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
  • Green MD; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.
  • Li S; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. migr@med.umich.edu.
  • Sun Y; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA. migr@med.umich.edu.
  • Journey SN; Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, USA. migr@med.umich.edu.
  • Choi JE; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
  • Rizvi SM; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.
  • Qin A; Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
  • Waninger JJ; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
  • Lang X; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
  • Chopra Z; University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA.
  • El Naqa I; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Zhou J; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Bian Y; Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.
  • Jiang L; Division of Hematology Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
  • Tezel A; University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA.
  • Skvarce J; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Achar RK; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
  • Sitto M; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.
  • Rosen BS; University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA.
  • Su F; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
  • Narayanan SP; Machine Learning Department, Moffitt Cancer Center, Tampa, FL, USA.
  • Cao X; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
  • Wei S; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.
  • Szeliga W; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
  • Vatan L; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.
  • Mayo C; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.
  • Morgan MA; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
  • Schonewolf CA; University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA.
  • Cuneo K; University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA.
  • Kryczek I; University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA.
  • Ma VT; University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Lao CD; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
  • Lawrence TS; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
  • Ramnath N; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Wen F; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Chinnaiyan AM; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Cieslik M; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Alva A; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Zou W; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
Nat Med ; 27(1): 152-164, 2021 01.
Article em En | MEDLINE | ID: mdl-33398162
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T / Imunoterapia / Neoplasias Hepáticas / Neoplasias Hepáticas Experimentais / Macrófagos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T / Imunoterapia / Neoplasias Hepáticas / Neoplasias Hepáticas Experimentais / Macrófagos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos