Inhibition of canine distemper virus replication by blocking pyrimidine nucleotide synthesis with A77 1726, the active metabolite of the anti-inflammatory drug leflunomide.

Li, Yao; Yi, Li; Cheng, Sipeng; Wang, Yongshan; Wang, Jiongjiong; Sun, Jing; Zhang, Quan; Xu, Xiulong

Li, Yao; Yi, Li; Cheng, Sipeng; Wang, Yongshan; Wang, Jiongjiong; Sun, Jing; Zhang, Quan; Xu, Xiulong.

Afiliação

Li Y; College of Veterinary Medicine, Institute of Comparative Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, PR China.
Yi L; State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Economic Animals and Plant Science, Chinese Academy of Agricultural Sciences, Changchun, PR China.
Cheng S; State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Economic Animals and Plant Science, Chinese Academy of Agricultural Sciences, Changchun, PR China.
Wang Y; Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, National Center for Engineering Research of Veterinary Bio-products, Nanjing 210014, PR China.
Wang J; College of Veterinary Medicine, Institute of Comparative Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, PR China.
Sun J; College of Veterinary Medicine, Institute of Comparative Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, PR China.
Zhang Q; Institutes of Agricultural Science and Technology Development, Yangzhou University Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou, PR China.
Xu X; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou University, Yangzhou 225009, Jiangsu Province, PR China.

J Gen Virol ; 102(3)2021 03.

Article em En | MEDLINE | ID: mdl-33416466

Assuntos

Antivirais/farmacologia; Crotonatos/farmacologia; Vírus da Cinomose Canina/efeitos dos fármacos; Hidroxibutiratos/farmacologia; Nitrilas/farmacologia; Nucleotídeos de Pirimidina/biossíntese; Toluidinas/farmacologia; Animais; Compostos de Bifenilo/farmacologia; Chlorocebus aethiops; Crotonatos/antagonistas & inibidores; Meios de Cultivo Condicionados; Di-Hidro-Orotato Desidrogenase; Vírus da Cinomose Canina/fisiologia; Hidroxibutiratos/antagonistas & inibidores; Imidazóis/farmacologia; Janus Quinases/antagonistas & inibidores; Leflunomida/metabolismo; Nitrilas/antagonistas & inibidores; Proteínas do Nucleocapsídeo/metabolismo; Oxirredutases atuantes sobre Doadores de Grupo CH-CH/antagonistas & inibidores; Fosforilação; Piperazinas/farmacologia; RNA Interferente Pequeno/genética; Proteínas Quinases S6 Ribossômicas 70-kDa/antagonistas & inibidores; Proteínas Quinases S6 Ribossômicas 70-kDa/genética; Toluidinas/antagonistas & inibidores; Uridina/farmacologia; Células Vero; Proteínas da Matriz Viral/metabolismo; Replicação Viral/efeitos dos fármacos

Palavras-chave

A77 1726; canine distemper virus; dihydroorotate dehydrogenase; janus kinase; leflunomide; p70 S6 kinase 1; pyrimidine nucleotide synthesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Nucleotídeos de Pirimidina / Toluidinas / Crotonatos / Vírus da Cinomose Canina / Hidroxibutiratos / Nitrilas Limite: Animals Idioma: En Revista: J Gen Virol Ano de publicação: 2021 Tipo de documento: Article

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