Physiologically based pharmacokinetic modeling of altered tizanidine systemic exposure by CYP1A2 modulation: Impact of drug-drug interactions and cigarette consumption.

Jogiraju, Vamshi Krishna; Heimbach, Tycho; Toderika, Yuliana; Taft, David R

Jogiraju, Vamshi Krishna; Heimbach, Tycho; Toderika, Yuliana; Taft, David R.

Afiliação

Jogiraju VK; Samuel J. and Joan B. Williamson Institute for Pharmacometrics, Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY, 11201, USA.
Heimbach T; Department of PK Sciences, PBPK and Biopharmaceutics Section, Novartis Institutes for Biomedical Research, East Hanover, NJ, 07936, USA.
Toderika Y; Division of Pharmacy Practice, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY, 11201, USA.
Taft DR; Samuel J. and Joan B. Williamson Institute for Pharmacometrics, Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY, 11201, USA. Electronic address: david.taft@liu.edu.

Drug Metab Pharmacokinet ; 37: 100375, 2021 Apr.

Article em En | MEDLINE | ID: mdl-33561738

Assuntos

Fumar Cigarros/metabolismo; Clonidina/análogos & derivados; Citocromo P-450 CYP1A2/metabolismo; Produtos do Tabaco/efeitos adversos; Biotransformação; Clonidina/farmacocinética; Interações Medicamentosas; Humanos

Palavras-chave

CYP1A2; Drug-drug interaction; Fluvoxamine; PBPK model; Tizanidine

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Clonidina / Citocromo P-450 CYP1A2 / Produtos do Tabaco / Fumar Cigarros Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Drug Metab Pharmacokinet Assunto da revista: FARMACOLOGIA / METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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