FRET imaging revealed that nanocrystals enhanced drug oral absorption by dissolution rather than endocytosis: A case study of coumarin 6.

Zhang, Guangshuai; Wang, Yunzhi; Zhang, Zuopeng; He, Zhonggui; Liu, Yang; Fu, Qiang

Zhang, Guangshuai; Wang, Yunzhi; Zhang, Zuopeng; He, Zhonggui; Liu, Yang; Fu, Qiang.

Afiliação

Zhang G; Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China.
Wang Y; Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China.
Zhang Z; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China.
He Z; Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China.
Liu Y; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China. Electronic address: y.liu@syphu.edu.cn.
Fu Q; Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China. Electronic address: fuqiang@syphu.edu.cn.

J Control Release ; 332: 225-232, 2021 04 10.

Article em En | MEDLINE | ID: mdl-33640408

Assuntos

Nanopartículas; Preparações Farmacêuticas; Administração Oral; Animais; Disponibilidade Biológica; Cumarínicos; Endocitose; Transferência Ressonante de Energia de Fluorescência; Ratos; Ratos Sprague-Dawley; Reprodutibilidade dos Testes; Solubilidade; Tiazóis; Distribuição Tecidual

Palavras-chave

Dissolution; Drug nanocrystals; Endocytosis; In vivo trafficking; Oral absorption

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Nanopartículas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Control Release Assunto da revista: FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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