LRRK2 Kinase Activity Does Not Alter Cell-Autonomous Tau Pathology Development in Primary Neurons.

Henderson, Michael X; Changolkar, Lakshmi; Trojanowski, John Q; Lee, Virginia M Y

Henderson, Michael X; Changolkar, Lakshmi; Trojanowski, John Q; Lee, Virginia M Y.

Afiliação

Henderson MX; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA.
Changolkar L; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Trojanowski JQ; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lee VMY; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

J Parkinsons Dis ; 11(3): 1187-1196, 2021.

Article em En | MEDLINE | ID: mdl-33720852

Assuntos

Doença de Parkinson; Animais; Encéfalo/metabolismo; Humanos; Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina/genética; Corpos de Lewy/metabolismo; Mutação/genética; Neurônios/metabolismo; Doença de Parkinson/genética

Palavras-chave

G2019S; Leucine-rich repeat kinase 2; Mapt; genetic risk; kinase inhibition

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson Limite: Animals / Humans Idioma: En Revista: J Parkinsons Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google