Conventional MRI findings in hereditary degenerative ataxias: a pictorial review.
Neuroradiology
; 63(7): 983-999, 2021 Jul.
Article
em En
| MEDLINE
| ID: mdl-33733696
ABSTRACT
PURPOSE:
Cerebellar ataxias are a large and heterogeneous group of disorders. The evaluation of brain parenchyma via MRI plays a central role in the diagnostic assessment of these conditions, being mandatory to exclude the presence of other underlying causes in determining the clinical phenotype. Once these possible causes are ruled out, the diagnosis is usually researched in the wide range of hereditary or sporadic ataxias.METHODS:
We here propose a review of the main clinical and conventional imaging findings of the most common hereditary degenerative ataxias, to help neuroradiologists in the evaluation of these patients.RESULTS:
Hereditary degenerative ataxias are all usually characterized from a neuroimaging standpoint by the presence, in almost all cases, of cerebellar atrophy. Nevertheless, a proper assessment of imaging data, extending beyond the mere evaluation of cerebellar atrophy, evaluating also the pattern of volume loss as well as concomitant MRI signs, is crucial to achieve a proper diagnosis.CONCLUSION:
The integration of typical neuroradiological characteristics, along with patient's clinical history and laboratory data, could allow the neuroradiologist to identify some conditions and exclude others, addressing the neurologist to the more appropriate genetic testing.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ataxia Cerebelar
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Neuroradiology
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Itália