Synthesis of Moracin C and Its Derivatives with a 2-arylbenzofuran Motif and Evaluation of Their PCSK9 Inhibitory Effects in HepG2 Cells.

Masagalli, Jagadeesh Nagarajappa; BasavanaGowda, Melanayakanakatte Kuberappa; Chae, Hee-Sung; Choi, Won Jun

Masagalli, Jagadeesh Nagarajappa; BasavanaGowda, Melanayakanakatte Kuberappa; Chae, Hee-Sung; Choi, Won Jun.

Afiliação

Masagalli JN; College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University, Seoul 04620, Korea.
BasavanaGowda MK; College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University, Seoul 04620, Korea.
Chae HS; College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University, Seoul 04620, Korea.
Choi WJ; College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University, Seoul 04620, Korea.

Molecules ; 26(5)2021 Mar 02.

Article em En | MEDLINE | ID: mdl-33801308

Assuntos

Benzofuranos/química; Inibidores Enzimáticos/síntese química; Inibidores Enzimáticos/farmacologia; Inibidores de PCSK9; Estilbenos/química; Proliferação de Células; Células Hep G2; Humanos

Palavras-chave

HepG2 cell lines; cardiovascular diseases; low-density lipoprotein cholesterol; moracin compounds; proprotein convertase subtilisin/kexin type 9; structure activity relationships

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estilbenos / Benzofuranos / Inibidores Enzimáticos / Inibidores de PCSK9 Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2021 Tipo de documento: Article

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