Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location.
Elife
; 102021 04 06.
Article
em En
| MEDLINE
| ID: mdl-33821790
ABSTRACT
The hippocampus plays a central role in long-term memory formation, and different hippocampal network states are thought to have different functions in this process. These network states are controlled by neuromodulatory inputs, including the cholinergic input from the medial septum. Here, we used optogenetic stimulation of septal cholinergic neurons to understand how cholinergic activity affects different stages of spatial memory formation in a reward-based navigation task in mice. We found that optogenetic stimulation of septal cholinergic neurons (1) impaired memory formation when activated at goal location but not during navigation, (2) reduced sharp wave ripple (SWR) incidence at goal location, and (3) reduced SWR incidence and enhanced theta-gamma oscillations during sleep. These results underscore the importance of appropriate timing of cholinergic input in long-term memory formation, which might help explain the limited success of cholinesterase inhibitor drugs in treating memory impairment in Alzheimer's disease.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sono
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Neurônios Colinérgicos
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Aprendizagem Espacial
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Navegação Espacial
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Memória Espacial
Limite:
Animals
Idioma:
En
Revista:
Elife
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Reino Unido