Streamlining differential exon and 3' UTR usage with diffUTR.
BMC Bioinformatics
; 22(1): 189, 2021 Apr 13.
Article
em En
| MEDLINE
| ID: mdl-33849458
ABSTRACT
BACKGROUND:
Despite the importance of alternative poly-adenylation and 3' UTR length for a variety of biological phenomena, there are limited means of detecting UTR changes from standard transcriptomic data.RESULTS:
We present the diffUTR Bioconductor package which streamlines and improves upon differential exon usage (DEU) analyses, and leverages existing DEU tools and alternative poly-adenylation site databases to enable differential 3' UTR usage analysis. We demonstrate the diffUTR features and show that it is more flexible and more accurate than state-of-the-art alternatives, both in simulations and in real data.CONCLUSIONS:
diffUTR enables differential 3' UTR analysis and more generally facilitates DEU and the exploration of their results.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Poli A
/
Biologia Computacional
Idioma:
En
Revista:
BMC Bioinformatics
Assunto da revista:
INFORMATICA MEDICA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
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