Several frailty parameters highly prevalent in middle age (50-65) are independent predictors of adverse events.
Sci Rep
; 11(1): 8774, 2021 04 22.
Article
em En
| MEDLINE
| ID: mdl-33888851
ABSTRACT
Although frailty can arise in middle age, very few studies have investigated frailty before 65 years. Our objectives were to assess the prevalence of frailty parameters in middle-aged individuals and probe the association with future adverse events. We performed cross-sectional and longitudinal analyses of community-dwelling individuals aged 50 to 65 (n = 411, median age 59.0) having undergone a multidomain geriatric assessment (2010-2015) in an outpatient clinic in the greater Paris area of France (SUCCEED cohort). The primary outcome was a composite measure of adverse events (non-accidental falls, fractures, unplanned hospitalizations, death), recorded in 2016/2017. Multivariable logistic regression models were built to identify independent predictors. Six frailty parameters were highly prevalent (> 20%) low activity (40.1%), exhaustion (31.3%), living alone (28.5%), balance impairment (26.8%), weakness (26.7%), and executive dysfunction (23.2%). Female sex (odds ratio 2.67 [95% confidence interval 1.17-6.11]), living alone (2.39 [1.32-4.33]), balance impairment (2.09 [1.16-3.78]), executive dysfunction (2.61, [1.18-5.77]), and exhaustion (2.98 [1.65-5.39]) were independent predictors of adverse events. Many frailty parameters are already altered in middle-aged individuals and are predictive of adverse health events. Our findings highlight a possible need for frailty screening and preventive programs targeting middle-aged individuals.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acidentes por Quedas
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Idoso Fragilizado
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Morte
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Hospitalização
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Sci Rep
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
França