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Pharmacological inhibition of PI5P4Kα/ß disrupts cell energy metabolism and selectively kills p53-null tumor cells.
Chen, Song; Chandra Tjin, Caroline; Gao, Xiang; Xue, Yi; Jiao, Haoyan; Zhang, Ruilin; Wu, Mengnan; He, Zunyu; Ellman, Jonathan; Ha, Ya.
Afiliação
  • Chen S; Department of Pharmacology, Yale School of Medicine, New Haven, CT 06520.
  • Chandra Tjin C; Department of Chemistry, Yale University, New Haven, CT 06520.
  • Gao X; Department of Pharmacology, Yale School of Medicine, New Haven, CT 06520.
  • Xue Y; Department of Pharmacology, Yale School of Medicine, New Haven, CT 06520.
  • Jiao H; Department of Pharmacology, Yale School of Medicine, New Haven, CT 06520.
  • Zhang R; Department of Pharmacology, Yale School of Medicine, New Haven, CT 06520.
  • Wu M; Department of Pharmacology, Yale School of Medicine, New Haven, CT 06520.
  • He Z; Department of Pharmacology, Yale School of Medicine, New Haven, CT 06520.
  • Ellman J; Department of Pharmacology, Yale School of Medicine, New Haven, CT 06520.
  • Ha Y; Department of Chemistry, Yale University, New Haven, CT 06520.
Proc Natl Acad Sci U S A ; 118(21)2021 05 25.
Article em En | MEDLINE | ID: mdl-34001596
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Fosfotransferases (Aceptor do Grupo Álcool) / Bibliotecas de Moléculas Pequenas / Neoplasias Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Fosfotransferases (Aceptor do Grupo Álcool) / Bibliotecas de Moléculas Pequenas / Neoplasias Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article