Design, synthesis, and insecticidal activities of propargyloxy-naphthalene-sulfonamide derivatives.
J Asian Nat Prod Res
; 24(4): 361-370, 2022 Apr.
Article
em En
| MEDLINE
| ID: mdl-34042537
ABSTRACT
In our previous studies, a kind of novel benzenesulfonamides was found to be a candidate insecticidal compounds. It was shown that propargyloxy and sulfonamide groups are pharmacodynamic groups. One hundred and twenty-six (126) naphthalenesulfonamides derivatives with propargyloxy functionality were designed and synthesized, and their insecticidal activities were determined. Some of them showed outstanding activity, with LC50 values as low as 0.202 mg ml-1, much lower than that of the positive control celangulin V (23.9 mg ml-1). In addition, the structure-activity relationships were discussed, and molecular docking was used to verify the binding mode of the compound and the target receptor.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Inseticidas
Idioma:
En
Revista:
J Asian Nat Prod Res
Assunto da revista:
BOTANICA
/
QUIMICA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China