Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease.
Biomedicines
; 9(5)2021 May 14.
Article
em En
| MEDLINE
| ID: mdl-34068971
ABSTRACT
The applications of 3D bioprinting are becoming more commonplace. Since the advent of tissue engineering, bone has received much attention for the ability to engineer normal bone for tissue engraftment or replacement. While there are still debates on what materials comprise the most durable and natural replacement of normal tissue, little attention is given to recreating diseased states within the bone. With a better understanding of the cellular pathophysiology associated with the more common bone diseases, these diseases can be scaled down to a more throughput way to test therapies that can reverse the cellular pathophysiology. In this review, we will discuss the potential of 3D bioprinting of bone tissue in the following disease states osteoporosis, Paget's disease, heterotopic ossification, osteosarcoma, osteogenesis imperfecta, and rickets disease. The development of these 3D bioprinted models will allow for the advancement of novel therapy testing resulting in possible relief to these chronic diseases.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Biomedicines
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos