Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor.

Cornblath, Eli J; Li, Howard L; Changolkar, Lakshmi; Zhang, Bin; Brown, Hannah J; Gathagan, Ronald J; Olufemi, Modupe F; Trojanowski, John Q; Bassett, Danielle S; Lee, Virginia M Y; Henderson, Michael X

Cornblath, Eli J; Li, Howard L; Changolkar, Lakshmi; Zhang, Bin; Brown, Hannah J; Gathagan, Ronald J; Olufemi, Modupe F; Trojanowski, John Q; Bassett, Danielle S; Lee, Virginia M Y; Henderson, Michael X.

Afiliação

Cornblath EJ; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA.
Li HL; Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Changolkar L; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Zhang B; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Brown HJ; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gathagan RJ; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Olufemi MF; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Trojanowski JQ; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bassett DS; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lee VMY; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA.
Henderson MX; Department of Electrical and Systems Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA.

Sci Adv ; 7(24)2021 06.

Article em En | MEDLINE | ID: mdl-34108219

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Sci Adv Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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