Novel pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety: design, synthesis, molecular docking, and biological evaluation as potential multi-target cytotoxic agents.

Shawky, Ahmed M; Ibrahim, Nashwa A; Abdalla, Ashraf N; Abourehab, Mohammed A S; Gouda, Ahmed M

Shawky, Ahmed M; Ibrahim, Nashwa A; Abdalla, Ashraf N; Abourehab, Mohammed A S; Gouda, Ahmed M.

Afiliação

Shawky AM; Science and Technology Unit (STU), Umm Al-Qura University, Makkah, Saudi Arabia.
Ibrahim NA; Central Laboratory for Micro-analysis, Minia University, Minia, Egypt.
Abdalla AN; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Abourehab MAS; Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Gouda AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.

J Enzyme Inhib Med Chem ; 36(1): 1313-1333, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34154478

Assuntos

Antineoplásicos/farmacologia; Simulação de Acoplamento Molecular/métodos; Pirazóis/química; Antineoplásicos/química; Desenho de Fármacos; Humanos; Células MCF-7; Tubulina (Proteína)/química

Palavras-chave

Pyrrolizine; apoptosis; cell cycle; cytotoxicity; kinase inhibitor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Simulação de Acoplamento Molecular / Antineoplásicos Limite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Arábia Saudita

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