Impact of cumulative fluid balance on the pharmacokinetics of extended infusion meropenem in critically ill patients with sepsis.

Parízková, Renata Cerná; Martínková, Jirina; Havel, Eduard; Safránek, Petr; Kaska, Milan; Astapenko, David; Bezouska, Jan; Chládek, Jaroslav; Cerný, Vladimír

Parízková, Renata Cerná; Martínková, Jirina; Havel, Eduard; Safránek, Petr; Kaska, Milan; Astapenko, David; Bezouska, Jan; Chládek, Jaroslav; Cerný, Vladimír.

Afiliação

Parízková RC; Department of Anesthesiology, Resuscitation and Intensive Medicine, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 50005, Hradec Králové, Czech Republic.
Martínková J; Department of Surgery, University Hospital Hradec Králové, Sokolská 581, 50005, Hradec Králové, Czech Republic.
Havel E; Department of Surgery, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 50005, Hradec Králové, Czech Republic.
Safránek P; Department of Surgery, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 50005, Hradec Králové, Czech Republic.
Kaska M; Department of Surgery, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 50005, Hradec Králové, Czech Republic.
Astapenko D; Department of Anesthesiology, Resuscitation and Intensive Medicine, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 50005, Hradec Králové, Czech Republic.
Bezouska J; Department of Surgery, University Hospital Hradec Králové, Sokolská 581, 50005, Hradec Králové, Czech Republic.
Chládek J; Department of Pharmacology, Charles University, Faculty of Medicine in Hradec Králové, Simkova 870, 50003, Hradec Králové, Czech Republic. chladekj@lfhk.cuni.cz.
Cerný V; Department of Anesthesiology, Resuscitation and Intensive Medicine, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 50005, Hradec Králové, Czech Republic.

Crit Care ; 25(1): 251, 2021 07 17.

Article em En | MEDLINE | ID: mdl-34274013

Assuntos

Meropeném/farmacocinética; Farmacocinética; Sepse/tratamento farmacológico; Equilíbrio Hidroeletrolítico/efeitos dos fármacos; APACHE; Adulto; Idoso; Idoso de 80 Anos ou mais; Antibacterianos/metabolismo; Antibacterianos/farmacocinética; Teorema de Bayes; Estado Terminal/terapia; República Tcheca; Feminino; Humanos; Unidades de Terapia Intensiva/organização & administração; Unidades de Terapia Intensiva/estatística & dados numéricos; Masculino; Meropeném/metabolismo; Pessoa de Meia-Idade; Estudos Prospectivos; Sepse/fisiopatologia

Palavras-chave

Critically ill patients; Fluid therapy; Meropenem; Pharmacodynamics; Pharmacokinetics; Sepsis

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Equilíbrio Hidroeletrolítico / Farmacocinética / Sepse / Meropeném Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Crit Care Ano de publicação: 2021 Tipo de documento: Article País de afiliação: República Tcheca

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google