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Acetylation of the Catalytic Lysine Inhibits Kinase Activity in PI3Kδ.
Fournier, Julie C L; Evans, John P; Zappacosta, Francesca; Thomas, Daniel A; Patel, Vipulkumar K; White, Gemma V; Campos, Sebastien; Tomkinson, Nicholas C O.
Afiliação
  • Fournier JCL; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Evans JP; Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.
  • Zappacosta F; Arctoris, 120E Olympic Avenue, Milton Park, Oxford, OX14 4SA, United Kingdom.
  • Thomas DA; GSK, South Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Patel VK; Arctoris, 120E Olympic Avenue, Milton Park, Oxford, OX14 4SA, United Kingdom.
  • White GV; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Campos S; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Tomkinson NCO; Pharmaron, West Hill Innovation Park, Hertford Road, Hoddesdon, Hertfordshire EN11 9FH, United Kingdom.
ACS Chem Biol ; 16(9): 1644-1653, 2021 09 17.
Article em En | MEDLINE | ID: mdl-34397208
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Acrilamidas / Adenina / Classe I de Fosfatidilinositol 3-Quinases / Afatinib / Inibidores de Fosfoinositídeo-3 Quinase / Compostos de Anilina / Lisina Limite: Humans Idioma: En Revista: ACS Chem Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Acrilamidas / Adenina / Classe I de Fosfatidilinositol 3-Quinases / Afatinib / Inibidores de Fosfoinositídeo-3 Quinase / Compostos de Anilina / Lisina Limite: Humans Idioma: En Revista: ACS Chem Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido