Divergent synthesis and elaboration of structure activity relationship for quinoline derivatives as highly selective NTPDase inhibitor.

Murtaza, Amna; Afzal, Saira; Zaman, Gohar; Saeed, Aamer; Pelletier, Julie; Sévigny, Jean; Iqbal, Jamshed; Hassan, Abbas

Murtaza, Amna; Afzal, Saira; Zaman, Gohar; Saeed, Aamer; Pelletier, Julie; Sévigny, Jean; Iqbal, Jamshed; Hassan, Abbas.

Afiliação

Murtaza A; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Afzal S; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan.
Zaman G; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Saeed A; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Pelletier J; Centre de recherche du CHU de Québec - Université Laval, Québec City, QC, Canada.
Sévigny J; Centre de recherche du CHU de Québec - Université Laval, Québec City, QC, Canada; Département de Microbiologie-Infectiologie et d'Immunologie, Faculté de Médecine, Université Laval, Québec City, QC, Canada.
Iqbal J; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan. Electronic address: drjamshed@cuiatd.edu.pk.
Hassan A; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan. Electronic address: ahassan@qau.edu.pk.

Bioorg Chem ; 115: 105240, 2021 10.

Article em En | MEDLINE | ID: mdl-34416508

Assuntos

Adenosina Trifosfatases/antagonistas & inibidores; Apirase/antagonistas & inibidores; Inibidores Enzimáticos/farmacologia; Quinolinas/farmacologia; Adenosina Trifosfatases/metabolismo; Apirase/metabolismo; Relação Dose-Resposta a Droga; Inibidores Enzimáticos/síntese química; Inibidores Enzimáticos/química; Humanos; Estrutura Molecular; Quinolinas/síntese química; Quinolinas/química; Relação Estrutura-Atividade

Palavras-chave

Human nucleoside triphosphate diphosphohydrolases (h-NTPDases); Iodine catalysis; Molecular docking studies; Quinoline derivatives; Structure activity relationship

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apirase / Quinolinas / Adenosina Trifosfatases / Inibidores Enzimáticos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Paquistão

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