Parallel evaluation of cell­based phage display panning strategies: Optimized selection and depletion steps result in AML blast­binding consensus antibodies.

Weber, Theresa; Pscherer, Sibylle; Gamerdinger, Ulrike; Teigler-Schlegel, Andrea; Rutz, Natalja; Blau, Wolfgang; Rummel, Mathias; Gattenlöhner, Stefan; Tur, Mehmet Kemal

Parallel evaluation of cellbased phage display panning strategies: Optimized selection and depletion steps result in AML blastbinding consensus antibodies.

Weber, Theresa; Pscherer, Sibylle; Gamerdinger, Ulrike; Teigler-Schlegel, Andrea; Rutz, Natalja; Blau, Wolfgang; Rummel, Mathias; Gattenlöhner, Stefan; Tur, Mehmet Kemal.

Afiliação

Weber T; Institute of Pathology, Justus Liebig University Giessen, University Hospital Giessen and Marburg, D35392 Giessen, Germany.
Pscherer S; Institute of Pathology, Justus Liebig University Giessen, University Hospital Giessen and Marburg, D35392 Giessen, Germany.
Gamerdinger U; Institute of Pathology, Justus Liebig University Giessen, University Hospital Giessen and Marburg, D35392 Giessen, Germany.
Teigler-Schlegel A; Institute of Pathology, Justus Liebig University Giessen, University Hospital Giessen and Marburg, D35392 Giessen, Germany.
Rutz N; Institute of Pathology, Justus Liebig University Giessen, University Hospital Giessen and Marburg, D35392 Giessen, Germany.
Blau W; Department for Hematology, Oncology and Palliative Care, Helios Dr Horst Schmidt Kliniken, D65199 Wiesbaden, Germany.
Rummel M; Department for Hematology, Justus Liebig University Giessen, University Hospital Giessen and Marburg, D35392 Giessen, Germany.
Gattenlöhner S; Institute of Pathology, Justus Liebig University Giessen, University Hospital Giessen and Marburg, D35392 Giessen, Germany.
Tur MK; Institute of Pathology, Justus Liebig University Giessen, University Hospital Giessen and Marburg, D35392 Giessen, Germany.

Mol Med Rep ; 24(5)2021 Nov.

Article em En | MEDLINE | ID: mdl-34490477

Assuntos

Anticorpos Monoclonais/imunologia; Anticorpos Antineoplásicos/imunologia; Técnicas de Visualização da Superfície Celular/métodos; Imunoterapia/métodos; Leucemia Mieloide Aguda/terapia; Especificidade de Anticorpos; Bacteriófagos/imunologia; Células HEK293; Humanos; Cultura Primária de Células

Palavras-chave

acute myeloid leukemia; consensus phage; depletion antigen diversity; enrichment of blasts; internalizing antibody; phage display technology

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Técnicas de Visualização da Superfície Celular / Imunoterapia / Anticorpos Monoclonais / Anticorpos Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Mol Med Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha

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