An <i>in silico</i> kinetic model of 8-oxo-7,8-dihydro-2-deoxyguanosine and 8-oxo-7,8-dihydroguanosine metabolism from intracellular formation to urinary excretion.

Jorgensen, Anders; Thygesen, Maria Bremholm; Kristiansen, Uffe; Poulsen, Henrik Enghusen

An in silico kinetic model of 8-oxo-7,8-dihydro-2-deoxyguanosine and 8-oxo-7,8-dihydroguanosine metabolism from intracellular formation to urinary excretion.

Jorgensen, Anders; Thygesen, Maria Bremholm; Kristiansen, Uffe; Poulsen, Henrik Enghusen.

Afiliação

Jorgensen A; Institute of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Thygesen MB; Psychiatric Center Copenhagen (Rigshospitalet), Mental Health Services of the Capital Region, Copenhagen, Denmark.
Kristiansen U; Department of Drug Design and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Poulsen HE; Department of Drug Design and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Scand J Clin Lab Invest ; 81(7): 540-545, 2021 Nov.

Article em En | MEDLINE | ID: mdl-34511003

Assuntos

8-Hidroxi-2'-Desoxiguanosina/metabolismo; 8-Hidroxi-2'-Desoxiguanosina/urina; Simulação por Computador; Guanosina/análogos & derivados; Espaço Intracelular/metabolismo; DNA/metabolismo; Guanosina/metabolismo; Guanosina/urina; Cinética; RNA/metabolismo

Palavras-chave

8-oxo-7,8-dihydro-2-deoxyguanosine; 8-oxo-7,8-dihydroguanosine; DNA; DNA repair; RNA; kinetics; oxidative stress

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Simulação por Computador / Espaço Intracelular / 8-Hidroxi-2'-Desoxiguanosina / Guanosina Idioma: En Revista: Scand J Clin Lab Invest Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Dinamarca

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