The genetics of human performance.
Nat Rev Genet
; 23(1): 40-54, 2022 01.
Article
em En
| MEDLINE
| ID: mdl-34522035
ABSTRACT
Human physiology is likely to have been selected for endurance physical activity. However, modern humans have become largely sedentary, with physical activity becoming a leisure-time pursuit for most. Whereas inactivity is a strong risk factor for disease, regular physical activity reduces the risk of chronic disease and mortality. Although substantial epidemiological evidence supports the beneficial effects of exercise, comparatively little is known about the molecular mechanisms through which these effects operate. Genetic and genomic analyses have identified genetic variation associated with human performance and, together with recent proteomic, metabolomic and multi-omic analyses, are beginning to elucidate the molecular genetic mechanisms underlying the beneficial effects of physical activity on human health.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Resistência Física
/
Exercício Físico
/
Proteômica
/
Estudo de Associação Genômica Ampla
/
Metabolômica
/
Biologia Molecular
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Nat Rev Genet
Assunto da revista:
GENETICA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos