Development of Genetically Encoded Biosensors for Reporting the Methyltransferase-Dependent Biosynthesis of Semisynthetic Macrolide Antibiotics.

Li, Yiwei; Reed, Megan; Wright, H Tonie; Cropp, T Ashton; Williams, Gavin J

Li, Yiwei; Reed, Megan; Wright, H Tonie; Cropp, T Ashton; Williams, Gavin J.

Afiliação

Li Y; Department of Chemistry, NC State University, Raleigh, North Carolina 27695, United States.
Reed M; Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, United States.
Wright HT; Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, Virginia 23219, United States.
Cropp TA; Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, United States.
Williams GJ; Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, Virginia 23219, United States.

ACS Synth Biol ; 10(10): 2520-2531, 2021 10 15.

Article em En | MEDLINE | ID: mdl-34546703

Assuntos

Antibacterianos/biossíntese; Técnicas Biossensoriais/métodos; Macrolídeos/metabolismo; Metiltransferases/metabolismo; Antibacterianos/química; Macrolídeos/química; Estrutura Molecular; Mutagênese

Palavras-chave

biosensor; macrolide; polyketide; synthetic biology; transcription factor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Técnicas Biossensoriais / Macrolídeos / Metiltransferases / Antibacterianos Idioma: En Revista: ACS Synth Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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