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A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19.
Huo, Jiandong; Mikolajek, Halina; Le Bas, Audrey; Clark, Jordan J; Sharma, Parul; Kipar, Anja; Dormon, Joshua; Norman, Chelsea; Weckener, Miriam; Clare, Daniel K; Harrison, Peter J; Tree, Julia A; Buttigieg, Karen R; Salguero, Francisco J; Watson, Robert; Knott, Daniel; Carnell, Oliver; Ngabo, Didier; Elmore, Michael J; Fotheringham, Susan; Harding, Adam; Moynié, Lucile; Ward, Philip N; Dumoux, Maud; Prince, Tessa; Hall, Yper; Hiscox, Julian A; Owen, Andrew; James, William; Carroll, Miles W; Stewart, James P; Naismith, James H; Owens, Raymond J.
Afiliação
  • Huo J; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus, Didcot, UK.
  • Mikolajek H; Division of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Le Bas A; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Science Campus, Didcot, UK.
  • Clark JJ; Diamond Light Source Ltd, Harwell Science Campus, Didcot, UK.
  • Sharma P; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus, Didcot, UK.
  • Kipar A; Division of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Dormon J; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Science Campus, Didcot, UK.
  • Norman C; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
  • Weckener M; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
  • Clare DK; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
  • Harrison PJ; Laboratory for Animal Model Pathology, Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
  • Tree JA; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus, Didcot, UK.
  • Buttigieg KR; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Science Campus, Didcot, UK.
  • Salguero FJ; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus, Didcot, UK.
  • Watson R; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Science Campus, Didcot, UK.
  • Knott D; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus, Didcot, UK.
  • Carnell O; Diamond Light Source Ltd, Harwell Science Campus, Didcot, UK.
  • Ngabo D; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Science Campus, Didcot, UK.
  • Elmore MJ; Diamond Light Source Ltd, Harwell Science Campus, Didcot, UK.
  • Fotheringham S; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
  • Harding A; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
  • Moynié L; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
  • Ward PN; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
  • Dumoux M; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
  • Prince T; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
  • Hall Y; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
  • Hiscox JA; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
  • Owen A; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
  • James W; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
  • Carroll MW; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus, Didcot, UK.
  • Stewart JP; Division of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Naismith JH; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Science Campus, Didcot, UK.
  • Owens RJ; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus, Didcot, UK.
Nat Commun ; 12(1): 5469, 2021 09 22.
Article em En | MEDLINE | ID: mdl-34552091
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anticorpos Neutralizantes / Anticorpos de Domínio Único / Glicoproteína da Espícula de Coronavírus / Tratamento Farmacológico da COVID-19 Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anticorpos Neutralizantes / Anticorpos de Domínio Único / Glicoproteína da Espícula de Coronavírus / Tratamento Farmacológico da COVID-19 Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido