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Development of bifunctional anti-PD-L1 antibody MMAE conjugate with cytotoxicity and immunostimulation.
Xiao, Dian; Luo, Longlong; Li, Jiaguo; Wang, Zhihong; Liu, Lianqi; Xie, Fei; Feng, Jiannan; Zhou, Xinbo.
Afiliação
  • Xiao D; National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
  • Luo L; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
  • Li J; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
  • Wang Z; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
  • Liu L; National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
  • Xie F; National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
  • Feng J; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address: fengjiannan1970@qq.com.
  • Zhou X; National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address: zhouxinbo@bmi.ac.cn.
Bioorg Chem ; 116: 105366, 2021 11.
Article em En | MEDLINE | ID: mdl-34560561
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Imunoconjugados / Anticorpos Monoclonais Humanizados / Antígeno B7-H1 / Desenvolvimento de Medicamentos / Imunoterapia / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Imunoconjugados / Anticorpos Monoclonais Humanizados / Antígeno B7-H1 / Desenvolvimento de Medicamentos / Imunoterapia / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China