Serotonin type-3 receptor antagonists selectively kill melanoma cells through classical apoptosis, microtubule depolymerisation, ERK activation, and NF-&#954;B downregulation.

Barzegar-Fallah, Anita; Alimoradi, Houman; Dunlop, Jessica L; Torbati, Elham; Baird, Sarah K

Serotonin type-3 receptor antagonists selectively kill melanoma cells through classical apoptosis, microtubule depolymerisation, ERK activation, and NF-κB downregulation.

Barzegar-Fallah, Anita; Alimoradi, Houman; Dunlop, Jessica L; Torbati, Elham; Baird, Sarah K.

Afiliação

Barzegar-Fallah A; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.
Alimoradi H; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.
Dunlop JL; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.
Torbati E; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.
Baird SK; Department of Biochemistry, University of Otago, Dunedin, New Zealand.

Cell Biol Toxicol ; 39(3): 1119-1135, 2023 06.

Article em En | MEDLINE | ID: mdl-34654991

Assuntos

Antieméticos; Melanoma; Humanos; Antieméticos/efeitos adversos; Ondansetron/efeitos adversos; Tropizetrona/efeitos adversos; Serotonina/efeitos adversos; NF-kappa B; Vômito/induzido quimicamente; Vômito/tratamento farmacológico; Vômito/prevenção & controle; Regulação para Baixo; Simulação de Acoplamento Molecular; Melanoma/tratamento farmacológico; Apoptose; Paclitaxel/farmacologia

Palavras-chave

5-HT3; Antagonist; Antiemetic; Cytoskeleton; Serotonin; Tubulin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Melanoma / Antieméticos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Biol Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Nova Zelândia

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