Protein PGLYRP1/Tag7 Peptides Decrease the Proinflammatory Response in Human Blood Cells and Mouse Model of Diffuse Alveolar Damage of Lung through Blockage of the TREM-1 and TNFR1 Receptors.

Sharapova, Tatiana N; Romanova, Elena A; Chernov, Aleksandr S; Minakov, Alexey N; Kazakov, Vitaly A; Kudriaeva, Anna A; Belogurov, Alexey A; Ivanova, Olga K; Gabibov, Alexander G; Telegin, Georgii B; Yashin, Denis V; Sashchenko, Lidia P

Sharapova, Tatiana N; Romanova, Elena A; Chernov, Aleksandr S; Minakov, Alexey N; Kazakov, Vitaly A; Kudriaeva, Anna A; Belogurov, Alexey A; Ivanova, Olga K; Gabibov, Alexander G; Telegin, Georgii B; Yashin, Denis V; Sashchenko, Lidia P.

Afiliação

Sharapova TN; Laboratory of Molecular Immunogenetics of Cancer, Institute of Gene Biology RAS, Vavilova 34/5, 111394 Moscow, Russia.
Romanova EA; Laboratory of Molecular Immunogenetics of Cancer, Institute of Gene Biology RAS, Vavilova 34/5, 111394 Moscow, Russia.
Chernov AS; Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 142290 Pushchino, Russia.
Minakov AN; Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 142290 Pushchino, Russia.
Kazakov VA; Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 142290 Pushchino, Russia.
Kudriaeva AA; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Belogurov AA; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Ivanova OK; Laboratory of Molecular Immunogenetics of Cancer, Institute of Gene Biology RAS, Vavilova 34/5, 111394 Moscow, Russia.
Gabibov AG; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Telegin GB; Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 142290 Pushchino, Russia.
Yashin DV; Laboratory of Molecular Immunogenetics of Cancer, Institute of Gene Biology RAS, Vavilova 34/5, 111394 Moscow, Russia.
Sashchenko LP; Laboratory of Molecular Immunogenetics of Cancer, Institute of Gene Biology RAS, Vavilova 34/5, 111394 Moscow, Russia.

Int J Mol Sci ; 22(20)2021 Oct 18.

Article em En | MEDLINE | ID: mdl-34681871

Assuntos

Lesão Pulmonar Aguda/patologia; Citocinas/química; Peptídeos/metabolismo; Receptores Tipo I de Fatores de Necrose Tumoral/metabolismo; Receptor Gatilho 1 Expresso em Células Mieloides/metabolismo; Lesão Pulmonar Aguda/metabolismo; Animais; Citocinas/genética; Citocinas/metabolismo; Modelos Animais de Doenças; Humanos; Interferon gama/genética; Interferon gama/metabolismo; Leucócitos Mononucleares/citologia; Leucócitos Mononucleares/efeitos dos fármacos; Leucócitos Mononucleares/metabolismo; Lipopolissacarídeos/farmacologia; Pulmão/metabolismo; Pulmão/patologia; Ativação Linfocitária/efeitos dos fármacos; Masculino; Camundongos; Camundongos Endogâmicos ICR; Peptídeos/química; Peptídeos/farmacologia; Ligação Proteica; Receptores Tipo I de Fatores de Necrose Tumoral/antagonistas & inibidores; Receptor Gatilho 1 Expresso em Células Mieloides/antagonistas & inibidores

Palavras-chave

COVID-19; TNFR1; TREM-1; Tag7; acute lung injury; cytokines

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Citocinas / Receptores Tipo I de Fatores de Necrose Tumoral / Lesão Pulmonar Aguda / Receptor Gatilho 1 Expresso em Células Mieloides Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Federação Russa

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