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Obesity and cancer death in white and black adults: A prospective cohort study.
Brown, Justin C; Yang, Shengping; Mire, Emily F; Wu, Xiaocheng; Miele, Lucio; Ochoa, Augusto; Zabaleta, Jovanny; Katzmarzyk, Peter T.
Afiliação
  • Brown JC; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
  • Yang S; School of Medicine, LSU Health New Orleans, New Orleans, Louisiana, USA.
  • Mire EF; Stanley S. Scott Cancer Center, LSU Health New Orleans, New Orleans, Louisiana, USA.
  • Wu X; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
  • Miele L; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
  • Ochoa A; School of Medicine, LSU Health New Orleans, New Orleans, Louisiana, USA.
  • Zabaleta J; Stanley S. Scott Cancer Center, LSU Health New Orleans, New Orleans, Louisiana, USA.
  • Katzmarzyk PT; School of Public Health/Louisiana Tumor Registry, LSU Health New Orleans, New Orleans, Louisiana, USA.
Obesity (Silver Spring) ; 29(12): 2119-2125, 2021 12.
Article em En | MEDLINE | ID: mdl-34693655
OBJECTIVE: This study aimed to determine whether race modifies the association between obesity and cancer death. METHODS: The Pennington Center Longitudinal Study included 18,296 adults; 35.0% were male and 34.3% were Black. The primary end point was death from cancer. RESULTS: During a follow-up of 14.3 years, 346 cancer deaths occurred. Among men, race modified the association of BMI and cancer death (pinteraction = 0.045); compared with a BMI of 22 kg/m2 , a BMI of 35 in White men was associated with a hazard ratio of 1.74 (95% CI: 1.38-2.21), and in Black men, the hazard ratio was 0.64 (95% CI: 0.45-0.90). Among women, race did not modify the association of BMI and cancer death (pinteraction =0.43); however, compared with a BMI of 22, a BMI of 35 in White women was associated with a hazard ratio of 1.42 (95% CI: 1.18-1.70) and in Black women, the hazard ratio was 0.99 (95% CI: 0.82-1.20). CONCLUSIONS: In this diverse cohort of adults, having obesity was associated with an increased risk of cancer death in White men and women. In contrast, having obesity was associated with a reduced risk of cancer death in Black men and did not influence risk in Black women.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: População Branca / Neoplasias Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Obesity (Silver Spring) Assunto da revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: População Branca / Neoplasias Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Obesity (Silver Spring) Assunto da revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos