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IL-27 signalling promotes adipocyte thermogenesis and energy expenditure.
Wang, Qian; Li, Dehai; Cao, Guangchao; Shi, Qiping; Zhu, Jing; Zhang, Mingyue; Cheng, Hao; Wen, Qiong; Xu, Hao; Zhu, Leqing; Zhang, Hua; Perry, Rachel J; Spadaro, Olga; Yang, Yunfan; He, Shengqi; Chen, Yong; Wang, Baocheng; Li, Guangqiang; Liu, Zonghua; Yang, Caixian; Wu, Xiaoli; Zhou, Libing; Zhou, Qinghua; Ju, Zhenyu; Lu, Hongyun; Xin, Yongjie; Yang, Xiaoyong; Wang, Cunchuan; Liu, Yong; Shulman, Gerald I; Dixit, Vishwa Deep; Lu, Ligong; Yang, Hengwen; Flavell, Richard A; Yin, Zhinan.
Afiliação
  • Wang Q; Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
  • Li D; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
  • Cao G; Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
  • Shi Q; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
  • Zhu J; Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
  • Zhang M; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
  • Cheng H; Department of Endocrine, The First Affiliated Hospital, Jinan University, Guangzhou, China.
  • Wen Q; Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
  • Xu H; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
  • Zhu L; Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
  • Zhang H; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
  • Perry RJ; Key Laboratory for the Genetics of Developmental & Neuropsychiatric Disorders (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China.
  • Spadaro O; Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
  • Yang Y; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
  • He S; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
  • Chen Y; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
  • Wang B; The First Affiliated Hospital, Faculty of Medical Science, Jinan University, Guangzhou, China.
  • Li G; Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
  • Liu Z; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
  • Yang C; Department of Medicine, School of Medicine, Yale University, New Haven, CT, USA.
  • Wu X; Department of Cellular & Molecular Physiology, School of Medicine, Yale University, New Haven, CT, USA.
  • Zhou L; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
  • Zhou Q; Department of Comparative Medicine, School of Medicine, Yale University, New Haven, CT, USA.
  • Ju Z; Department of Comparative Medicine, School of Medicine, Yale University, New Haven, CT, USA.
  • Lu H; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Institute for Advanced Studies, Wuhan University, Wuhan, China.
  • Xin Y; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Institute for Advanced Studies, Wuhan University, Wuhan, China.
  • Yang X; Tsinghua Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen, China.
  • Wang C; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
  • Liu Y; The First Affiliated Hospital, Faculty of Medical Science, Jinan University, Guangzhou, China.
  • Shulman GI; Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
  • Dixit VD; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
  • Lu L; Department of Endocrine, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China.
  • Yang H; School of Life Sciences, Tianjin University, Tianjin, China.
  • Flavell RA; Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, China.
  • Yin Z; Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
Nature ; 600(7888): 314-318, 2021 12.
Article em En | MEDLINE | ID: mdl-34819664
ABSTRACT
Thermogenesis in brown and beige adipose tissue has important roles in maintaining body temperature and countering the development of metabolic disorders such as obesity and type 2 diabetes1,2. Although much is known about commitment and activation of brown and beige adipose tissue, its multiple and abundant immunological factors have not been well characterized3-6. Here we define a critical role of IL-27-IL-27Rα signalling in improving thermogenesis, protecting against diet-induced obesity and ameliorating insulin resistance. Mechanistic studies demonstrate that IL-27 directly targets adipocytes, activating p38 MAPK-PGC-1α signalling and stimulating the production of UCP1. Notably, therapeutic administration of IL-27 ameliorated metabolic morbidities in well-established mouse models of obesity. Consistently, individuals with obesity show significantly decreased levels of serum IL-27, which can be restored after bariatric surgery. Collectively, these findings show that IL-27 has an important role in orchestrating metabolic programs, and is a highly promising target for anti-obesity immunotherapy.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adipócitos / Termogênese / Metabolismo Energético / Interleucina-27 Tipo de estudo: Health_economic_evaluation / Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Nature Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
Texto completo
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adipócitos / Termogênese / Metabolismo Energético / Interleucina-27 Tipo de estudo: Health_economic_evaluation / Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Nature Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China