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Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE).
Parhiz, Hamideh; Brenner, Jacob S; Patel, Priyal N; Papp, Tyler E; Shahnawaz, Hamna; Li, Qin; Shi, Ruiqi; Zamora, Marco E; Yadegari, Amir; Marcos-Contreras, Oscar A; Natesan, Ambika; Pardi, Norbert; Shuvaev, Vladimir V; Kiseleva, Raisa; Myerson, Jacob W; Uhler, Thomas; Riley, Rachel S; Han, Xuexiang; Mitchell, Michael J; Lam, Kieu; Heyes, James; Weissman, Drew; Muzykantov, Vladimir R.
Afiliação
  • Parhiz H; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: parhizh@pennmedicine.upenn.edu.
  • Brenner JS; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia
  • Patel PN; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Papp TE; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Shahnawaz H; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Li Q; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Shi R; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Zamora ME; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia
  • Yadegari A; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Marcos-Contreras OA; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Natesan A; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Pardi N; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Shuvaev VV; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Kiseleva R; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Myerson JW; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Uhler T; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Riley RS; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
  • Han X; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
  • Mitchell MJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Car
  • Lam K; Genevant Sciences Corporation, Vancouver, BC V5T 4T5, Canada.
  • Heyes J; Genevant Sciences Corporation, Vancouver, BC V5T 4T5, Canada.
  • Weissman D; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: dreww@pennmedicine.upenn.edu.
  • Muzykantov VR; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: muzykant@pennmedicine.upenn.edu.
J Control Release ; 344: 50-61, 2022 04.
Article em En | MEDLINE | ID: mdl-34953981
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanopartículas / COVID-19 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Control Release Assunto da revista: FARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanopartículas / COVID-19 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Control Release Assunto da revista: FARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article