The role of the protein tyrosine phosphatase SHP2 in ossification.
Dev Dyn
; 251(5): 748-758, 2022 05.
Article
em En
| MEDLINE
| ID: mdl-34962674
ABSTRACT
SHP2, encoded by the PTPN11 gene, participates in multiple cell functions including cell proliferation, movement, and differentiation. PTPN11 loss-of-function and gain-of-function mutations are both associated with diseases, such as Noonan syndrome, whose manifestations include bone defects, suggesting a crucial role for SHP2 in the skeleton. However, the exact mechanisms by which SHP2 regulates bone development remain unclear. This review focuses on the current understanding of the regulation of SHP2 and highlights the vital roles of SHP2 in skeletal development, especially its roles in ossification. Overall, a better understanding of the functions of SHP2 in ossification will provide a new avenue to treat-related skeletal diseases.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Osteogênese
/
Síndrome de Noonan
Limite:
Humans
Idioma:
En
Revista:
Dev Dyn
Assunto da revista:
ANATOMIA
Ano de publicação:
2022
Tipo de documento:
Article