Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer's disease.

Kim, Chae; Haldiman, Tracy; Kang, Sang-Gyun; Hromadkova, Lenka; Han, Zhuang Zhuang; Chen, Wei; Lissemore, Frances; Lerner, Alan; de Silva, Rohan; Cohen, Mark L; Westaway, David; Safar, Jiri G

Kim, Chae; Haldiman, Tracy; Kang, Sang-Gyun; Hromadkova, Lenka; Han, Zhuang Zhuang; Chen, Wei; Lissemore, Frances; Lerner, Alan; de Silva, Rohan; Cohen, Mark L; Westaway, David; Safar, Jiri G.

Afiliação

Kim C; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Haldiman T; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Kang SG; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton T6G 2M8, Canada.
Hromadkova L; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Han ZZ; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton T6G 2M8, Canada.
Chen W; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Lissemore F; National Prion Disease Pathology Surveillance Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Lerner A; Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
de Silva R; Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Cohen ML; Reta Lila Weston Institute of Neurological Studies and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 1PJ, UK.
Westaway D; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Safar JG; National Prion Disease Pathology Surveillance Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

Sci Transl Med ; 14(626): eabg0253, 2022 01 05.

Article em En | MEDLINE | ID: mdl-34985969

Assuntos

Doença de Alzheimer; Proteínas tau; Doença de Alzheimer/patologia; Humanos; Isoformas de Proteínas/metabolismo; Proteínas tau/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas tau / Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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